I wore the Moab Ventilator Mid on my trek last year. I am 6'3", hiked at about 235 lbs, 45lb pack. 80 mile total trek distance.
I was completely satisfied with these boots for the trek. They were a last minute switch for me because of a sole issue with the boots I had been prepping in. Switched about two weeks before the trek - risky, but I put about 50 miles on them before I left.
The one thing I found was these boots were too flexible for my size - I was getting a little bit of arch strain. I added the Superfeet green insole from REI to get just a little more stiffness and a little more cushion, and the combination worked great for me.
Even though I didn't get much break in or practice time, I had zero blisters on the trek. Not one. I wore the REI moreno wool socks, no liner, changed them each day (rotated 3 pr for the trek).
We had rain every day for the first 6 days, and my feet stayed dry.
I could not have been happier with these boots for my trek.