You can leave at home: plate, seat, aqua-mira or squeeze(no need for both),bucket, rain jacket or poncho(no need for both),camp shoes, dishwashing tool, light and extra batteries(unless I plan on night hiking, a small photon is enough).
You could easily go lighter:Waka waka(carry an extra battery instead; a single S4 charge lasts me several days; a second battery should be the most you need), rope(you can get much lighter line),gloves(light liners are good most of the seasons), first aid and toiletries kit are heavy(I typically only need a couple ounces for each, at most),light knife instead of a leatherman.
Maybe you can leave the inhaler and advair if you leave the smokes at home. Or maybe not; you know better than me. Or maybe its not worth it. Smokes are so personal and deeply ingrained.
Consider a light alky stove and lighter pot. Especially on short trips, alcohol or esbit shine on a weight basis.