I realize that there is a serious side to this topic, too, and that not all can be fun and games (although it has been fun). So, a serious response.
What I do---know thy potential predator, use common sense, and not let the presence of lions and bears prevent me from enjoying the outdoors. In the lower 48, even in grizz country, I generally have never bothered with firearms, sprays, or bladed weapons---either alone or travelling with others. In Canada and Alaska, I have carried pepper spray and once, a number of years ago, on the request of the NW territorial gov't, a rifle, as we were in a treeless subarctic region (Logans) w/ heavy brown bear presence and little human interaction.It was never used, was a heavy nuisance and the bears stayed at long binocular range (gawd, they were amazing)...
I have had some amazing sightings of both mountain lions and both black and grizzly bears. The lions were generally very shy, distracted by stalking their usual prey and fled at first sight of me. Black bears, I've had the most interaction with---I've never felt threatened by them but generally give them a respectful space but will lob a rock at them if they come too close to camp or kitchen----I've never lost any food to them, I practice sound food pro methods. Grizzly, I stay out of thickets, generally travel in terrain with long sightlines and have made detours to prevent close encounters. Never have been bluff charged, let alone attacked---so I've never had to test the spray. Perhaps I've been lucky, but I have been travelling among the top feeders for quite awhile. Ultimately, one picks their risk level and (hopefully) intelligently plans to recreate within it.