"Second would be focusing...do you use manual or AF, and on a related note, what f-stops or ISO would you recommend?"
I don't think that there is anything magic about operation on a backpack trip. I normally leave my camera in P mode and Live View, then let it rip. If it is in normal daylight, then you will have plenty of light, so the camera will figure out the exposure pretty easily. Focus is a bit tricky, simply because of the nature of the DSLR and how it does autofocus. If you are able to half-press to get the initial focus lock and then leave it there, it is the easiest. If your primary target is moving toward the camera (like wildlife), then it gets a lot trickier. Although it is possible to shoot handheld, you generally get much better results with the camera on a decent tripod with a smooth panning action. Sometimes that is not possible, so you can try to do it with image stabilization in the lens, but that makes some video viewers get motion sickness. Video also tends to eat up a lot of battery power, mostly because of the Live View display, so carry along lots of spare batteries. That adds weight, and that goes against our BPL creed.
Like all video shooting, you will get better results if you can plan out the entire shot in advance.