I've fortunately lived about a few hours from some very good backpacking since 1995 (except when deployed), so it's usually averaged about a weekend a month due to work, household chores, and other social commitments. Some months more, some less. Wildfires have interfered in 2011 and to a lesser degree, 2012
I went "feral" for about a year, backpacking every weekend, working during week, but it got old, so that got cut down to backpacking once or twice a month (more in the summer/less in winter). Love backpacking but there's biking, BBQ-ing, etc... watching the local university have another losing football season. In 2012 I spent much of May outdoors but did less into the summer (a few weekend trips, then a long distance one). Fall came and work gobbled up my Sundays. Get outdoors while you can I guess.
To answer your question, yes it makes a big difference when you can leave work Friday and sleep at the TH that night - before midnight. I've explored much of the 4 corners primo locations that way.