Plenty of great options. Several loop options in the Smokies. For example, go out of Big Creek and up the AT. Side trip to MT Cammerer. Come bazck on the other ridge thru MT Sterling.
Another favorite is the Roan Highlands section of the AT. But that will involve a shuttle
Linville Gorge has multiple loop options
Many other good loops in the Smokies out of Cosby, Cataloochie, Clingman's Dome, Fontana,etc that very nice
Shining Rock and Art Loeb in NC are worth considering
Shenandoah if youre willing to shuttle