I trail run in running shoes over a hundred days a year. They work well for me in relatively non technical terrain. As the terrain gets more technical, I tend to have mild ankle rolls. For backpacking, I move to trail runners that eliminate my ankle roll. I have found trail runners very somewhat in ankle control. This is an area for you to experiment and build personal understanding. Remember that your experiment is shoe specific rather than applicable to the whole shoe category.
Gaiters, rarely use them. They introduce an element of fuss factor and I don't have issues without them. For 20+ mile days my feet need a bit more care, partially due to dust and moisture in my socks. Gaitors could help in this regard, but I wash my feet, apply powder and/or change my socks rather than wear gators.