FWIW, here's my experience going from traditional full-leather goretex boots (Danner Mountain Lights) to mesh trail runners.
>Started with Keen Ridgeline (no longer made), @ 13 oz/shoe. Pretty traditional raised heel, padding, "support" etc. Nice wide toe box. Went through two pairs--these changed my mind about the need for boots and keeping feet dry.
>Next shoes were Inov8 Roclite 295s, @ ~11 oz/shoe. Narrower toe box than the Keens, but works for my feet, esp. upsizing a bit. Still some drop, heel to toe. Love the tread and sticky rubber soles. Definitely felt the difference in padding and structure, and changed my gait accordingly. First hike in them was 45 miles over two days. No blisters (but then I almost never get blisters), several mid-calf stream crossings (which would have swamped any shoes or boots, goretex or not), some manageable foot soreness that stopped short of bruising. Later in the season, had zero comfort issues on days that approached similar mileage. So I would say, in my experience, there's some period of getting used to a more minimal shoe, but with a transitional model like the 295s, it's not bad. If Trail Gloves don't ultimately work for me, I'd be happy going back to 295s.
>Current shoes are Trail Gloves, @ 7 oz/shoe. Trail Gloves are a zero drop shoe, and have very minimal padding (maybe 2mm?). More anatomical last than Inov8, at least for my feet. Since I got them a few months ago, I've used them on day hikes, as well as rough paths and hill climbs on my walk to work. I like them a lot, but there is an adjustment--even walking, I find heel striking painful (no big deal--it just keeps me on my mid and fore foot). Great ground feel. I'll have them backpacking for the first time this weekend, with maybe a 14 mile day as the longest.
>In my opinion, you'll notice a dramatic difference going from the shoes you've been using to something like the Minimus or Trail Glove. And there'll be adjustments.