Barlow for 2 nights, with day hike to Sykes as second day is nice. One caveat, Barlow is close to the trailhead, I wouldn't leave all the gear there unattended all day if I were you, there's a fair number of travelers who use the closer parts of Ventana to spend some weeks. Ie, leave someone there, or if you are traveling UL, just pack it up and take it along. Barlow is a great spot to hang out in though, the water is cold this time of year so it's probably not fun to swim the canyons and pools.
Another thing you can do is park at China Camp trailhead, then hike in to Bear Valley, Divide, or Pine Valley camps and take day trips from there. The advantage there is not having to hike up the thousands of feet of first day climbing from Botcher's Gap. Disadvantage is not being in the lower valley redwood ecosystem, but more of an alpine one. I read a recent trip report to Pat Springs, apparently a lot of dead fall all over from the fire, I haven' been there recently so can't say from firsthand. If you do park at China camp trailhead, make sure not to leave anything theft-worthy in the car, or visible.
Here's a nice tool:
google topo map of ventana (can't make it clickable, silly forum software...)
and for specific trail status: www.ventanawild.org
As always, remember poison oak and lyme bearing deer ticks. Tick nymphs start to appear April / May from what I read, and they are tiny, really really tiny, and also are the most infected percentage-wise compared to the adults.