"I tend to run through injuries as long as they are minor. usually back off the normal workout to an easy "rejuvenation" level, meaning shorter and less intense."
+1 Let pain be your guide. And keep it slow and short until you are back to normal.
"Re. ankle taping, I'd say it depends on if you are taping your ankle simply as a preventative, or you need it to get through your workout. you just need to listen to your body and not be stubborn."
Again, +1. I used to use it to be able to keep running, as long as the sprain was minor, and preventatively for races like The Dipsea or running really rough trails when training for same. If the sprain is serious, the pain should be enough to keep you from running on it, tape or no tape. If in doubt, don't run. Also, this might be a good time to get up close and personal with your local friendly Step Mill. The one thing you absolutely must avoid is going over on that ankle again. If you go over on it far enough, you risk knocking a bone chip off the inside head of the tibia, and that will put you down for a good long time, with possible surgery to remove it. Benn there, done that. Don't go there, Mike. Error on the side of caution. No single race/run, R2R2R included, is worth messing yourself up for the long run. If you've got good insurance, and the sprain is too sore to run on, this might not be a bad time to consult a good sports medicine physician or podiatrist, whichever has the better reputation in your locale.