My friend and I used these packs on the JMT last year, with a Bearikade Weekender inside. I wrapped a GG ThinLight pad around the can before placing it in the pack, which doubled as protection and insulation under the NeoAir at night. Wrapping the can in the pad protected it from rubbing through if the pack was leaned against a rock.
The packs fared well. Mine did come with some unfinished stitching on one of the pockets. This was fixed when they were sent back to have the shoulder straps modified. The straps were originally rubbing on my neck and inner arms, they came back perfect.
They could still both pass for new. I must admit that I'm super careful with my gear. Someone who is less careful, especially in the Sierra Nevada Mountains, with the rough granite, might have trouble with durability. I had no issues with the mesh, but if you plan to hike on brushy trails that are not frequently used, it may be tougher to keep the mesh in tact. Really, the only durability issues I can think of with this pack, or any, for that matter, can be avoided by just paying attention to where the pack is set down and steering clear of brush or other contacts. The weight we both carried was around 13-20 lbs, depending on availability of water and relation to resupply. I suppose if you were to overload this pack, the stitching on the straps could suffer, but if you are planning on 25 lbs, you shouldn't have issues in this regard.