Less inflation makes the pad more comfy, but can reduce insulative value. Finding a happy medium is key.
Some dabs/dots/strips of silicone sealant are often times helpful to reduce the slippery feel of an air mat. If you sleep in a quilt this becomes a non-issue because you lay directly on the mat rather than the slippery sleeping bag material sitting on top of it.
Benadryl is a really great trick too. Often times if I'm spending 24/7 outside, my sinuses that are used to spending all day in a filtered air office are unhappy by bedtime anyway, so the benadryl both opens my nasal passages, and knocks me the heck OUT. As long is it's not extraordinarily cold, noisy (bugs, animals, people, weather) or otherwise, it can be pretty easy to sleep much much better.