I'm a big fan of these supplements. They help me tremondously, but most, if not all of my pain is from the back breaking labor I have done all my life, the worst of which transmits through my wrists when pounding stakes and digging holes.
I first used something my dad had, I think it was Arthro-Servin, which help within a day or two. But it was serverly expensive. I've been taking Ostero Bo-Flex for years now, off and on. Seems to work within a week, and take it for 3-6 months. After that, my joints are ok for about the same amount of time. I'm almost done with a bottle of it, and am going to try Advocare's version, and see if there is any noticable difference.
Also, my wife has Outchscouth-slaader(sp?), which is in here right knee, and caused her extreme pain after walking more than 15 minutes at a time. The glucosamine and chondroitin seemd to help help a lot as well.