I'd recommend trying a trip using plastic bags. I started that way thinking I'd make some out of sil nylon, but never went back. It seems that people use grocery bags commonly, I use a bag that's about 3x thicker than grocery and can easily get 2+ days per bag (bring a few spares). Surprisingly the bags aren't uncomfortable (I don't even notice them) even though there is a fair amount of excess material due to the fact that they aren't fitted at all.
I've tried the Integral Designs VB socks and if anything they felt more uncomfortable than my plastic bags due to the thicker fabric.