Must weigh in here. I spend my summers doing research in the West Bank; I take a minimal amount of clothing and whatever goes needs to be comfortable and durable. Based on those two conditions, I decided on Ex Officio boxer briefs last year.
The smell, the mindbending eau-de-vagrant small-children-leave-the-room-and-animals-give-you-censorious-looks SMELL, after just two weeks, was so offensive that I stopped wearing underwear altogether. My colleagues eventually made a joke out of it, but given that in rural Arab culture bad smells are associated with bad omens, it was shaping up to be an actual impediment to my work.
This year, took Icebreaker 150 boxer briefs. No smell. Arguably less chafey. International incident averted. Your mileage may vary, but I am an ex-ex-officio user for life.