There are a ton of places to go in Alaska, and just as many opinions on which are the best spots to go. I worked as a guide on a small ship in Southeast AK through the Aleutians and Bering Sea, and also spent time running a private boat in the region. I've also spent a lot of time on land throughout that stretch.
If you're looking to get the broadest possible experience in Alaska within a 2-week period, the key will be limiting your travel time between regions. To do that, what I would recommend is taking half your time and heading up to Denali to do some backpacking, and the other half go kayaking in the Prince WIlliam Sound region. You can get a boat to shuttle you in and pick you back up through Whittier, which would allow you to fly in and out of Anchorage. This will give you the experiences of Denali (wildlife, views, etc) plus the contrasting but significant aquatic aspect of AK (glaciers, whales, orca, bears, etc).
If you don't have your heart set on Denali (and it is amazing, but I depending on what you want to see if may not be at the top of the priority list for Alaska), there are other regions to consider, such as the east arm of Glacier Bay or the Haines area, among many other good options. Feel free to shoot me a PM if you have questions.