The Sesquehannock Trail System (the orange blaze trail) is THE best trail I've ever backpacked in the east, including large sections of the AT in Virginia. The STS links several other great trails like The Black Forest Trail, that's why they call it a "system".
GOOGLE the STS and buy their excellent guidebook & three custom topo maps. Well worth the price. I love that trail. At about 5:30 on the loop is a tiny hamlet W/a Post Office where you can send the food, etc. for your last 1/2 of the trail. The 1st two weeks of October are spectacular for fall colors.
BTW, the Northern Gateway (trailhead) has safe parking at the PA Forestry's parking lot. A short 1/2 mile trail gets you to the STS.
(Also, I did a big part of the Quehanna Trail and was not impressed.)