Christopher, feel free to PM me if you ever feel like it. I could suggest many excellent hikes depending on what you're looking for. Here's a few ideas:
The Quehanna Wild Area / Elk State Forest is my all-time PA favorite - challenging and ridiculously beautiful. It's a big region, remote by eastern standards, but some weekenders are possible. Elk and black bear sightings are common in spring and fall. There are off-trail options if you really want an adventure, but the trails alone kept me interested for over a decade. Just don't count on a lot of bailout options. The DNRC prints the best map.
The Elk Trail, north of Benezette / Medix Run, is an easier 19-mile section to see elk and get a feel for the region. A good drive on Rt 555 through that area is pretty fun too.
MST through Rothrock SF, including the Greenwood Spur, Jackson Trail, Alan Seeger & Detweiler Run. Many great loops are possible, and they're not nearly as isolated as the Quehanna (easy bailouts). Purplelizard.com prints a good basic map. The MST / Seven Mountains guidebook has better maps, and those include the Rim Trail around Pine Creek Gorge.
I'll second the Allegheny Front Trail, Black Moshannon, and Old Loggers.
Carol Crooker wrote a nice SUL article about an easy loop in Allegheny National Forest (not the footwear podcast). A search here turned up too much stuff to wade through unfortunately.
Half of the Chuck Keiper Trail in Sproul State Forest would be good for a weekend (the full trail makes a figure-eight).
Okay, I'll take a breath now. Have fun...