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I have used zip-crotch MEC long underwear for a while. You can't use it for cycling as the zip concentrates your weight on the seams+zip. I would work up to wearing the next-to-skin zip stuff just like breaking in new boots as the edges of the zipper seam can cause chafing when hiking.
Having said all that, they are the best solution for outhouse calls at -40C in the field.
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