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It's been my experience that for the basic nutritional information label, the lab experimentally determines the moisture content, fatty acids, cholesterol, simple sugars, complex carbohydrates, fiber, protein, and basic vitamins values of the sample. Caloric content is not determined directly, but is calculated with basic addition using the 9-4-4 method for digestible fat,carbs, and protein.
Without knowing if the assays to get a nutritional label are standardized, I can't say what the calorie value would mean on any label other than the ones I was looking to use. My guess would be, if the label lists the fiber, the lab went through the trouble to measure it in order to provide a more accurate calorie count in the context of human nutrition.
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