Yes, Big Sur's cash crop is Poison Oak. I can attest to that. But our last trip from 2-3 weeks ago represented a successful battle against the odds of exposure. Bring your Tecnu, wear long pants, try and identify the plant. Barring identification efforts, just wash your exposed skin, e.g. hands and lower arms, with cold water and Tecnu every so often.
You can find many water sources, and even dry camps are close to a resupply.
If the Ventanas become your target, see the recommendations from the "Intense Northern Ca Trip" thread.