I bought two pairs of these a few months ago, but I have yet to use them on any sort of long distance trip.
On my trip to Mt. Whitney on the High Sierra Trail last year, I did get small blisters between my toes and I am hoping that the Injini Socks will eliminate them.
Incidentally, when I was on top of Mt. Whitney, there was sa guy who had just finished the JMT and swore by the Injini socks saying that he did not have a single blister.