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Richard, I am no expert, but if you're saying the body produces more heat at alititude, that doesn't feel right to my subjective gut feelings. "After mixing with water vapour and expired CO2 in the lungs, oxygen diffuses down a pressure gradient to enter arterial blood around where its partial pressure is 100mmHg (13.3kPa).[2] Arterial blood flow delivers oxygen to the peripheral tissues, where it again diffuses down a pressure gradient into the cells and into their mitochondria. These bacteria-like cytoplasmic structures strip hydrogen from fuels (glucose, fats and some amino acids) to burn with oxygen to form water. Released energy (originally from the sun and photosynthesis) is stored as ATP, to be later used for energy requiring metabolism. The fuel's carbon is oxidized to CO2, which diffuses down its partial pressure gradient out of the cells into venous blood to finally be exhaled by the lungs. Experimentally, oxygen diffusion becomes rate limiting (and lethal) when arterial oxygen partial pressure falls to 40mmHg or below. If oxygen delivery to cells is insufficient for the demand (hypoxia), hydrogen will be shifted to pyruvic acid converting it to lactic acid. This temporary measure (anaerobic metabolism) allows small amounts of energy to be produced. Lactic acid build up in tissues and blood is a sign of inadequate mitochondrial oxygenation, which may be due to hypoxemia, poor blood flow (e.g. shock) or a combination of both.[4] If severe or prolonged it could lead to cell death…. To counter the effects of high-altitude diseases, the body must return arterial P02 toward normal. Acclimatization, the means by which the body adapts to higher altitudes, only partially restores P02 to standard levels. Hyperventilation, the body’s most common response to high-altitude conditions, increases alveolar P02 by raising the depth and rate of breathing. However, while P02 does improve with hyperventilation, it does not return to normal. Studies of miners and astronomers working at 3000 meters and above show improved aveolar P02 with full acclimatization, yet the P02 level remains equal to or even below the threshold for continuous oxygen therapy for patients with chronic obstructive pulmonary disease (COPD).[5] In addition, there are complications involved with acclimatization. Polycythemia, in which the body increases the number of red blood cells in circulation, thickens the blood, raising the danger that the heart can’t pump it.
In high-altitude conditions, only oxygen enrichment can counteract the effects of hypoxia. By increasing the concentration of oxygen in the air, the effects of lower barometric pressure are countered and the level of arterial P02 is restored toward normal capacity. A small amount of supplemental oxygen reduces the equivalent altitude in climate-controlled rooms. At 4000 m, raising the oxygen concentration level by 5 percent via an oxygen concentrator and an existing ventilation system provides an altitude of 3000 m, which is much more tolerable for the increasing number of low-landers who work in high altitude.[6] In a study of astronomers working in Chile at 5050 m, oxygen concentrators increased the level of oxygen concentration by 6 percent (that is, from 21 percent to 27 percent). The result was increased worker productivity, less fatigue, and improved sleep." (Wikipedia.)
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